目的:对不同产地丹参有效部位进行药效学比较并进行评价。方法:对8个不同产地丹参含丹参素及含丹参酮成分进行了ADP诱导的血小板聚集实验、凝血酶原时间的测定及MDA的测定,对实验结果进行聚类分析和综合药效评价。结果:8种丹参的两种提取物均具有抗血小板聚集,延长凝血酶原时间及降低MDA的作用。结论:就上述活性而言,山西产丹参野生及栽培药效近似且较优于其他产地,四川中江栽培、山东野生、河南栽培药效近似,优劣居中;陕西安康野生和河南栽培相对较差。

Objective: To compare the total effects of Salvia miltiorrhiza Bge. from different localities. Methods: ADP-induced platelet aggregation and thrombogen time and MDA in rats' brain in vitro have been determined, and cluster analysis and comprehensive evaluation method have also been used to evaluate the total effects of Salvia miltiorrhiza Bge. Results: Active components of Salvia miltiorrhiza Bge. have inhibited ADP-induced platelet aggregation, retarded blood-plasma coagulation induced by Ca2+-cephalin and reduced the MDA in rats' brain in vitro. Conclusion: The results indicate that the wild Salvia miltiorrhiza Bge. from Shanxi province is the best one among the 8 varieties and then the planting ones in Sichuan, wild ones in Shandong and planting ones in Henan. The wild Salvia miltiorrhiza Bge. in Ankang county of Shanxi Province and in Lu county of Henan province are the worse.

国家自然科学基金重点项目(39730500)