中医药治病的原则是“调整阴阳,以平为期”。以方剂为载体,注重整体,采用辨证论治的方法,进行综合治疗的思想符合现代治疗学的发展趋势。然而传统中医药缺乏对药效物质的微现分析和作用机理的科学阐释,成为影响中医药迅速发展的瓶颈。因此,以复方丹参方为范例,从方剂的配伍配比、作用机理、药效物质等方面进行系统的研究,不仅证实了复方丹参方多组分、多靶点治疗心血管病假说的科学性,而且为经典处方的二次开发提供了一种模式。本项工作将丰富现代药物治疗学,促进方剂配伍的科学诠释,开拓中药新药创制新思路,构建创新中药的理论基础。

The principle for the treatment of diseases in traditional Chinese medicine (TCM) lies in " regulating Yin-Yang to seek equilibrium of all parts of human body" . The thinking that with prescriptions as carriers attention is given to the integration and the methodology of treatment based on syndrome differentiation is adopted for integrated treatment, is in accord with the trends of the development of modern therapeutics. In traditional Chinese medicine, however, the deficiency in microscopic analysis of effective matters of drugs and the scientific explanation of their functional mechanisms have become bottle-necks in the development of TCM. Therefore, a systematic study of the compatibility and proportion of drugs in prescriptions and the functional mechanisms and effective matters of drugs has been carried out by taking the complex prescriptions of Radix Salvial Milti orrhizal as examples, which has not only proved that the hypothesis for the treatment of cardiovascular diseases by the multi-constituents and multi-targets of such prescriptions is a scientific one, but also offered a pattern for the second exploitation of classic prescriptions. This study will enrich the modern pharmaco-therapeutics, push forward the scientific explanation of compatibility of medicines in a prescription, create new ideas for the development of new Chinese medicines and build up a theoretical basis for the innovation of Chinese medicines.

科技部国家重点基础研究发展规划项目(973项目G1999054403)