新型药物开发制备过程中,需要对药物颗粒进行粒子设计,通过多层微胶囊化而得到复合包覆药物颗粒。药物包覆、微胶囊制备方法很多,可分为化学法、物理化学法、物理法。本文着重介绍了制备复合多层包覆药物颗粒的几种物理机械方法:复合杂化系统,高速椭圆转子混合法、喷流床包覆法。简要分析了该技术用于中药现代化加工的可能性。

In the process of development and preparation of new drugs it is necessary to do the design of particles of the granules of drugs in order to obtain complicatedly clad granules by the way of multi - layered micro - capsulation. There are a number of methods for the cladding and micro - capsulated preparation of drugs, such as those of chemistry, physico -chemistry and physics. This article mainly presents a few physico - mechanical methods for the preparation of complicatedly and multi - layeredly clad granules of drugs: the system of HYBRLDIZATION, mixture by high - speed elliptic rotor and cladding in jet - flow bed, and briefly analyzes the possibility of the application of these techniques to the processing of Chinese drugs in the modernization of traditional Chinese medicine.

清华大学基础研究基金项目(JC20001050)