目的:综述中药现代化7种高新技术:超临界流体萃取技术、毛细管电泳技术、大孔吸附树脂技术、生物芯片技术、中药指纹图谱技术、酶技术、膜分离技术在体内药物分析中的应用。方法:查阅和整理近5年国内外文献。结果:这7种中药现代化高新技术在样品前处理、样品分析等方面的应用为探究中药作用机制、质量标准的制定、监测临床用药、新药研究开发提供了新方法和思路。结论:这些技术的应用必能加速中药现代化、国际化的进程。

Objective:To summarize the application of the following seven technologies to the analysis of internal Chinese drugs in the modernization of traditional Chinese medicine （TCM）: supercritical fluid extraction, capillary electrophoresis, macroporous adsorption resin, biochip, TCM fingerprint, enzyme and membrane separation. Method To consult and sort out relevant articles published at home and abroad in the last five years. Result The application of the said technologies to the pre-processing and analysis of biological samples has provided a new method and idea for the exploration of the functional mechanisms and the establishment of quality standards of TCM , the monitoring of drugs applied in clinic and the R&D of new drugs. Conclusion The application of such technologies will surely speed up the progress of the modernization and internationalization of TCM.

辽宁省“国家省级工程中心建设”项目(2002403004)