目的:找出中药有效部位新药研究中的一些问题,探索解决办法,促进高效中药新药的研发。方法:采用分析论述的形式。结果:从另一角度提出了有效部位的概念;分析中药有效部位新药的特点和优势、影响中药进入国际主流医药市场的关键因素;对中药有效部位进行了深入思考,如有效部位和有效成分的区别、非有效部位的有效成分、微量成分的有效性、有效部位含量必须达50%以上的意义、指纹图谱与中药有效部位的关系等;对提高中药疗效的研究方法进行分析, 提倡用药效导向筛选高效中药有效部位。结论:在现阶段应坚持中药研究思路,深入开展比较药理学研究,认真分析和妥善处理研究中存在问题,加强高效中药有效部位新药的研究。

Objective: To find out problems existing in the study of new medicines made of total effective components extracted from one medicinal herb or several ones and probe approaches to their resolution in order to promote the development of new medicines with high effectiveness. Method: To take the method of analysis and exposition. Result: The conception of total effective components extracted from one medicinal herb or several ones are put forward from another angle; the characteristics and advantages of new medicines made of total effective components extracted from one medicinal herb or several ones as well as the key factors which prevent the entry of Chinese medicines into principal international markets of medical supplies are analyzed; deep consideration of the total effective components extracted from one medicinal herb or several ones is made, such as the difference between the total effective components and a single component extracted from one medicinal herb or several ones, effective components out of the total effective components, the effectiveness of micro constituents, the significance that the content of the total effective components must reach 50% of the total extracts from one medicinal herb or several ones, and the relationship between fingerprint and the total effective components extracted from one herb or several ones; and the study method for the improvement of the curative effect of Chinese medicines is analyzed, advocating to screen the total effective components extracted from one medicinal herb or several ones with high medicinal effectiveness. Conclusion: The thought of the study on Chinese medicinal herbs and medicines should persist and the study of comparative pharmacology should be deeply carried out in the present period of time, and the problems emerging from the studies should be seriously analyzed and appropriately delt with. The study of new medicines made of the total effective components extracted from one medicinal herb or several ones with high medicinal effectiveness should be strengthened.

国家十五重大科技专项-创新药物与中药现代化(863计划,2003AA2Z3254)黄芪生脉胶囊研究,负责人:吕圭源浙江省自然科学基金重大项目(ZB0205)中药有效部位研究,项目负责人:吕圭源