晚期糖基化终产物（advanced glycation end-products,AGEs）受体（receptor for advanced glycation end-products,RAGE）在糖尿病血管病变的发生发展过程中具有相当重要的作用, 可作为防治糖尿病血管病变的药物靶点。建立以RAGE为药靶的体内外筛药系统,用于中药提取物的筛选,将显著提高中药抗糖尿病血管病变有效成分的筛选效率及准确性,对于阐明中药治疗糖尿病血管病变的机制,加快中药现代化进程有重大意义。

The receptor of advanced glycation end - products （RAGE） has a greatly important role in the process of the occurrence and evolution of the vascular diseases caused by diabetes, therefore it can be taken as the target for the prevention and treatment of such diseases. The establishment of in vivo and in vitro screening systems with RAGE as their target to screen the extracts of Chinese medicinal materials will evidently improve the screening efficiency and accuracy of the effective components of Chinese medicinal materials resistant to vascular diseases caused by diabetes and have notable significance in the explanation of the mechanisms by which vascular diseases caused by diabetes can be treated by Chinese medicines and in the acceleration of the modernization of traditional Chinese medicine.

江苏省高新技术重点资助项目(BG2001041)糖尿病微血管病变中药靶基因芯片的研究