为了充分认识微细化工艺制备中药的特点,使之更好地利用这一技术,我们对常用中药三七、葛根和知母制成微粉后,从体外溶出、体内吸收及生物活性和安全性等进行了综合试验,并分别与按中国药典2000年版规定方法制备的三七、葛根和知母粉进行比较。结果表明:三七、葛根和知母制成微粉后能不同程度的改善其有效成分的溶出效率,使其在体内释放和吸收加快,在一定程度上保持了原有的活性,同时没有明显增加其毒性。研究提示:中药微细化在药物的溶出方面有其优势,但在实际应用中应针对所制备药物的理化特性,有选择的使用。

To fully know the characteristics of the preparation of Chinese herbal medicine by micro - technology so as to better the use of this technology a comprehensive experiment of in vitro dissolving - out and in vivo absorption as well as the bioactivity and safety of prepared fine powders of three Chinese medicinal herbs-pseud - ginseng, the root of kudzu vine and rhizoma anemarrhenae has been carried out and all the indications of them have been compared respectively with those of the powders of the said three medicinal herbs prepared according to the method assigned in the 2000 edition of the Chinese Pharmacopoeia. The result indicates that the dissolving - out rate of the effective components of the said three medicinal herbs can be improved in its degree when the herbs are worked into fine powders, and then their release and absorption in human body can speed up and in a given degree their original activity can be kept without apparent increase of toxicity. The study shows that the advantages of Chinese medicinal materials prepared by micro - technology can be demonstrated in the dissolution of their effective components, but in the practical application this technology should be used in accordance with the physico - chemical properties of the medicinal materials to be prepared and on a selective basis.

清华大学基础研究项目(JC2001050)微细化工艺制备3种中药的药理毒理学研究