本文介绍了中医证研究的进展,探讨了中医证研究的方法学问题,针对慢性乙型肝炎中医“证”分型的分子基础研究问题,提出了用现代生物芯片技术开展此项研究的基本思路,即采用基因表达谱芯片技术对比研究慢性乙型肝炎病程进展中不同“证”的基因表达谱差异,探讨慢性乙型肝炎中医“证”分型的基因调控网络。

This article presents the progress in the study of syndrome in traditional Chinese medicine and investigates its methodology and proposes, aiming at the basic research of molecules in the classification of syndrome types of chronic hepatitis B in traditional Chinese medicine, a basic thought of carrying out this study by modern bio - chip technology, i. e., probing into the genie networks of regulation and control in the classification of syndrome types of chronic hepatitis B in traditional Chinese medicine by the application of the technology of gene expression spectrum chip to comparatively study the difference between gene expression spectra of different "syndromes" emerging in the process of chronic hepatitis B.

国家重大基础研究前期专项课题(2002ccc00300):慢性肝炎中医“证”分型的分子基础研究