前胡为中国药典收载的常用中药,我们在对其化学成分和生物活性深入系统研究的过程中,逐渐形成了对中药活性成分研究思路和方法的认识。本文主要结合我们长期的研究工作, 综述了1993年后中药前胡在化学成分、质量标准、资源开发、有效成分的结构修饰与全合成以及药理活性方面的研究近况,其主要目的是介绍如何以前胡活性成分研究为基础,全面提高中药前胡的研究水平,并为新药开发奠定基础。对前胡的研究已初步建立起了活性成分的现代化研究模式,期望其研究思路与方法能为其它中药活性成分的研究提供参考。

Radix Peucedani is a common - used Chinese medicine in the Pharmacopeia of China. In the process of their deep and systematic study of the chemical components and bio - activities of this medicinal plant the authors have gradually understood the thinking and method of the study of bio - activities of Chinese medicine. This article mainly summarizes, in combination with the authors' long-term study in this area, their studies in the chemical components, the quality standards, the development of resources, the structural modification and total synthesis of effective components and pharmacological activity sine 1993, aiming ot how to all - roundly improve the study of Radix Peucedani and lay the foundation for the development of new Chinese drugs by the introduction of the study of the active components of this plant medicine. At present a modern mode of study on the active components of Radix Peucedani has initially be established and it is hoped that the thinking and method in this study can offer reference for the study of active components of other Chinese drugs.

国家自然科学基金资助项目(29872058):白花前胡丙素的结构修饰和构效关系研究，负责人：孔令义；高等学校优秀青年教师教学科研奖励计划资助项目(2000-91):从前胡属植物中寻找抗艾滋病活性成分，负责人：孔令义。