本文在总结中药复方化学研究体系的基础上借鉴系统生物学,提出了一种新的组学研究方法-化学物质组学。化学物质组是指一定条件下输入生物体系的所有化学物质（化学成分）组成的复杂化学体系,而化学物质组学就是研究化学物质组的组成及其相互关系的一种方法。作为新学科萌芽的探讨,作者提出了层次化的化学物质组学的研究策略和相应的技术,应用于中药方剂的研究,并以清开灵为例从三个层次阐述了化学物质组研究方法,介绍了中药方剂化学物质组学研究的过程。作者认为:化学物质组学为复杂化学体系的研究提供了方法支持,是现有系统生物学的发展和补充,为研究生物复杂系统与外部的化学复杂系统的相互作用提供了必要条件;中药方剂作用于人体的过程正是最典型的两个复杂系统的相互作用,因此,化学物质组学的应用对于中药方剂研究将起到重要的推动作用。

This article presents a new methodology, chemical matteromics, for the study of "omics" on the basis of summarizing chemical studies of the compound prescriptions of traditional Chinese medicine （TCM） and making use of systems biology for reference. Chemical matterome means a complex chemical system composed of all the chemical matters （chemical components） which come into biosystems in a given condition while chemical matteromics is a methodology for the study of the components of a chemical matterome and their relationship. To explore this new discipline, the authors of this article propose a strategy of gradational study of chemical matteromics and its corresponding technology and apply it to the study of TCM prescriptions. Taking compound prescription QingKailing for example, they expound the study on the method of chemical matteromes at three levels and describe the study on the process of the chemical matteromics of TCM prescriptions. They hold that chemical matteromics offers methodological support for the study of complex chemical system and constitutes the development and supplement of the present systems biology, thus providing a necessary condition for the study of the interreaction between the biological complex system and the chemical complex system outside.The process that TCM prescriptions function on human body most typically expresses the interreaction of the two complex systems. Therefore, chemical matteromics will play an important role in the promotion of the study of TCM prescriptions.

科学技术部“十五”攻关项目(2004BA72lAB)中成药安全性评价示范研究