重点研究微波辅助萃取工艺在中药制药工程技术领域中的应用。选择不同药用部位的中药,采用化学分析指标跟踪、药效学平行试验的评价方法,开展了比较系统的工艺技术研究。微波萃取小型设备及中试的研究结果表明:经过微波辐射后能较好地富集药材中的有效成分, 与传统回流提取工艺比较,微波辅助萃取技术不仅萃取时间短、溶剂用量少、有效物质更易溶出,可显著地提高提取效率,更具有提取过程环境清洁、操作简便,更易于实现自动化生产控制,其推广应用可望为现代中药新药的研究开发提供新途径及新工艺。本文还同时介绍运用微波辅助萃取技术开发两种中药六类新药的新进展。

In this article the research results of the two key projects "Application of Microwave-induced Extraction Technology to key Pharmaceutical technology of Traditional Chinese Medicine （TCM）" and "Study of Standardization and Industrialization of Microwave-aided Extraction Technology" both financed by the Ministry of Science and Technology and carried out by the National Research Centre for Pharmaceutical Engineering and Technology is summarized, in which the study on the application of microwave-aided extraction polytechnology in the area of TCM pharmaceutical engineering and technology is emphasized and a systematic study on the polytechnology is conducted by the assessment method of tracing the indexes of chemical analysis and the parallel experiments of pharmarcodynamics of different parts of TCM medicinal materials. The results of the studies carried out by small devices of microwave extraction and pilot test indicate that effective components of medicinal materials can be better enriched through microwave radiation, and by the application of microwave-aided extraction technology the duration of extraction is shorter, less solvent is available for extraction, effective matters can be easily dissolved out and the extraction efficiency can be remarkably improved in comparison with the traditional reflux extraction technology. Meanwhile, the environment of extraction is cleaner and the operation faciler so that it is easier to bring about automatic control of production, and the application and spread of this technology are expected to provide a new approach and a new technique for the R&D of new drugs of modern TCM. In addition, this article refers to a new progress in the development of two Chinese medicaments and 6 new drugs of TCM via microwave-aided extraction technology.

科技部重点科技攻关项目(99-929-02-14)微波诱导萃取技术在中药制药关键工艺技术中的应用研究科技部重点科技攻关项目(2004BA721A40)中药微波辅助萃取技术的标准化与产业化研究