目的:研究治疗冠心病中药复方缓释制剂的均衡释放度。方法:采用高效液相色谱法和气质联用法进行测定。结果:以丹酚酸B为指标的水溶性成分的溶出符合Higuchi方程,以丹参酮Ⅱ A为指标的脂溶性成分的溶出符合Higuchi方程,挥发性成分冰片的溶出符合一级方程和Higuchi方程。结论:高效液相色谱法具有快速、简便稳定等特点,可用于评价中药复方缓释制剂体外释放度,气质联用法可用于评价冰片的释放度。

Objective To study the balanced release of slow-release TCM compound preparations for the treatment of coronary heart disease. Method To conduct the test in the study by HPLC and combined GC-MS. Result The dissolving-out degree of water-soluble components of the said preparations with salvianolic acid B as index is up to Higuchi equation, that of liposoluble components of the preparations with Tanshimone Ⅱ A as index is in conformity to Higuchi equation and that of volatile components of bormeol accords with the first-order equation and Higuchi equation. Conclusion Owing to its characteristics of rapidity, convenience and stability HPLC can be used to assess the in vitro release degree of slow-release TCM compound preparations and the combined GC-MS be used to assess the release degree of bormeol.

国家自然基金项目(30472198)中药复方缓释制剂复杂成分均衡释放的研究国家中医药管理局项目(2004-05ZP50)治 疗冠心病中药复方缓释制剂均衡释放的研究广东省自然基金项目(04105450)治疗冠心痛中药复方缓释制荆复杂成分 均衡释放的研究