众多研究表明,苷类中药需经肠道中的微生物转化为苷元后方能产生药效,利用微生物发酵过程中产生的酶系,建立苷类中药体外转化模型,将苷类物质转化为相应的苷元,能有效提高活性成分的生物利用度。利用微生物将药材中的苷类成分转化为中间体苷元,过程简单,成本较低,不但可以将中间体开发为新剂型,而且符合中药炮制现代化的客观要求,也符合中药生产现代化和产品国际化的发展要求。

Various studies in the literature have demonstrated that traditional Chinese medicine (TCM) with glycosides as active components come into effect only when the glycosidic ingredients are transformed into the corresponding agly-cones by the intestine microbes. With utilizing the microbial enzymes produced in the fermentation of microorganisms, the external transformation of glycosides in TCM could be carried out. In addition, by the means of transforming glycosidic compounds to the corresponding aglycones, the bioavailability of the active principles could be improved effectively. Such a process is simple and economic, and could not only lead to the development of new formulations for the resultant intermediates but also confirm with the requirements of the modernization of the preparation and production, andthe internationalization of TCM.

四川省中医药管理局科研项目(200510020761．4)β-葡萄糖苷酶高产菌株发酵栀子的研究,