目的探讨六味地黄丸对糖尿病肾损害实验指标的影响。方法采用随机对照方法,将符合标准的86例患者分为治疗组和对照组。治疗组45例,口服降糖西药加服六味地黄丸,对照组41 例,单服降糖西药。共观察16周,检测24h尿蛋白定量、尿微白蛋白排泄率(UAE),尿α1-微球蛋白 (α1-MG)、血一氧化氮(NO),尿N-乙酰-β-氨基葡萄糖苷酶(NAG酶)、血β2-微球蛋白(β2-MG),血肌酐(Scr)等肾损害实验指标。结果六味地黄丸治疗组尿UAE,尿仅α1-MG,尿NAG酶、血β2-MG、血肌酐治疗后均较本组治疗前和对照组治疗后有明显下降,有显著性差异(P<0．01或P<0．05),肌酐清除率(Ccr)和尿。NO有明显上升,有显著性差异(P<0．05)。结论六味地黄丸对糖尿病肾病患者各项肾损害实验指标有明显的改善作用。

Objective: To study effect of Liuwei Dihuang pill on kidney function of patients with diabetic nephropathy. Methods: In group dividing, random method was adopted. In the study, 86 patients who were meet to criteria were selected. All the patients were divided into treatment group and control group. Forty-five patients in treatment group orally took hypoglycemic western drug combined with Liuwei Dihuang pill, and 41 patients in control group orally took hypo-glycemic western drug simply. The observation lasted for 16 weeks. Follow indexes indicating kidney injury were detected before and after treatment: quantitative determination of urine protein for 24 hours, contents of UAE, α1-MG and NAG enzyme in urine, contents of NO,β2-MG and Scr in blood. Results: In treatment group, the contents of UAE, α1-MG and NAG enzyme in urine, as well as contents of β2-MG and Scr in blood decreased significantly after treatment compared with those of before treatment (P<0.01 or P<0.05). At the same...更多 time, the contents of Ccr and NO in blood of treatment group increased obviously after treatment (P<0.05). Conclusion: The Liuwei Dihuang pill is effective to improve kidney function of the patients with diabetic nephropathy.