目的探讨六味地黄丸对糖皮质激素治疗肾病综合征增效减毒作用。方法采用随机分组对照法,将符合标准的92例患者分为试验组和对照组,两组均给予泼尼松,并予必要的对症处理。同时试验组48例,加服六味地黄丸。结果试验组总体疗效、Ⅰ型者疗效均显著优于对照组(P<0．05);尿蛋白定量、血浆白蛋白、TG、TC等指标两组均改善显著(P<0．05、0．01),但均以试验组为优(P<0．015);其复发率亦以试验组为低(P<0．05)。试验组出现的阴虚火旺证候积分值及副作用的发生率均较对照组为低(P< 0．05、0．01)。结论六味地黄丸能显著提高激素治疗肾病综合征的疗效、减少肾病综合征的复发,并能对抗激素的副作用,值得临床推广应用。

Objective: To explore synergy and atteunation effect of Liuwei Dihuang pill on the treatment of nephrotic syndrome with glucocorticoid. Methods: Ninety-two patients were selected according to criteria and random method was adopted. All the patient were divided into two groups: treatment group and control group. In treatment group, Pred-nisone combined with Liuwei Dihuang pill was orally administrated to 44 patients; while in control group, Prednisone was orally administrated simply to 48 patients. Results: The total therapeutic effect and therapeutic effect of type I in treatment group were both better than that of control group (P<0.05). The content of urine protein and contents of albumin, TG and TC decreased significantly compared to control group (P<0.05 or P<0.01). Compared to control group, the recurrence rate, the occurrence rate of side effects and syndrome score of hyperactivity of fire due to yin deficiency in treatment group was lower (P<0.05 or P<0.01). Concl...更多usion: The Liuwei Dihuang pill is effective to increase therapeutic effects of Hormone on nephrotic syndrome, decrease recurrence, and reduce side effects of Hormone, which is worth to be applied widely.