目的：观察广防已分别与大黄、川芎、桂枝、茯苓、黄芪配伍后肾毒性的改变情况。方法：广防已分别与上述5味中药配伍,灌服大鼠60d后,测定血肌酐(Scr)、尿β_2-微球蛋白(β_2-MG)、尿碱性磷酸酶(AKP)、尿溶茵酶(Lys),并观察肾脏病理,与灌服广防已组大鼠进行比较。结果：与单味广防已组比较,配伍桂枝组和配伍黄芪组尿AKP有显著降低(P＜0.05),各配伍组组织病理学检查均无异常。结论：各配伍药物均可减轻其副作用,以桂枝、黄芪最为明显。

objective To observe amelioration of kidney toxicity of Radix Aristolochiae fangchi after matching respectively with Radix et Rhizoma Rhei,Rhizoma Ligustici Chuanxiong,Ramulus Cinnamomi,Poria and Radix Astragali.Methods: Radix Aristolochiae fangchi matched respectively with the above herbs and taken orally by rats in different groups for 60 days,Concentration of serum creatinine(Scr),urineβ_2-microglobulin(β_2-MG),alkaline phosphatase(AKP),lysozyme (Lys) were measured and pathologic changs of kidney were observed after 60 days.Results compared with the only Radix Aristolochiae fangchi group,the concentrations of AKP were significantly lower (p＜0.05) in the groups matching respectively with Ramulus Cinnamomi and Radix Astragali.Edema of renal tubular epithelial cell took place in the only Radix Aristolochiae fangchi group by pathologic examination of kidney,other groups are normal.Conclusion:after matching with the above herbs,the kidney toxicity decreased,especially Ramulus Cinnamomi a...更多nd Radix Astragali.

四川省科技厅重点项目(NO．025SY029-110):运用配伍方法缓解马兜铃酸不良反应的实验研究