目的：研究白芍、人参、干姜、甘草、大黄与附子各炮制品配伍前后有效成分含量的变化。方法：以芍药苷、人参皂苷、辣椒素、甘草酸单铵盐、大黄素为对照品,采用HPLC法测定,对比白芍、人参、干姜、甘草、大黄与附子配伍前后其有效成分的含量变化。结果：配伍后诸药有效成分含量明显低于药材单煎液。结论：附子与白芍、人参、干姜、甘草、大黄配伍后,附子毒性降低,与其配伍的五味中药药材中的有效成分亦有变化。

Objective:To study the changes of the contents of the active components in white peony,ginseng,dried ginger, licorice,and rhubarb after they were combined with aconite and its processed products.Methods:Using paeoniflorin, ginsenoside,capsaicin,ammonium glycyrrhizate and emodin as the chemical reference standards,which were deter- mined by HPLC in 5 Chinese medicinals after they were combined with aconite and its products.Results:After com- bined with aconite,the contents of the active components in the combined decoctions were obviously lower than that in the decoctions of individual medicinals.Conclusion:When aconite was combined with white peony,ginseng,dried gin- ger,licorice,or rhubarb,the toxicity of aconite was decreased;The active components of the medicinals combined with aconite were influenced,and as well.

国家自然科学基金(30230410):乌头类有毒中药安全性研究