本文提出了与多靶点效应有本质区别的中药方剂的整体调节效应即整体效应的观点,认为在目前尚难对中药化学成份进行性味、归经和升降沉浮等准确定位的情况下,方剂的整体效应只能依靠尽可能多地保持其中能被吸收的化学物质来实现,尤其不能忽视其中大量低丰度的成分及微量元素。提出必须充分重视胃肠道作用途径对中药方剂疗效的影响,中药方剂中真正的(药物分子或前体即)效应分子应是存在于消化吸收后进入血液循环前的那些物质之中,认为它们才是中药方剂整体效应的物质基础,并提出了中药方剂的整体效应分子组及整体效应分子组学的概念。

Chinese traditional herbs are medical materials which are used to treat“syndrome”according to syndrome differention,based on the curative principles and therapeutic methods.They are composed of different kinds of medical materials,processed in a special method,and they have distinguished characteristics and tastes,attributive channels and effects.The herbs are compatilized on principles of monach,minister,adjuvant and dispatcher.Therefore,the Chinese traditional herb has its special quality,different in essence from the natural medicine (such as animals,plants,mineral, etc).The modernization of Chinese traditional herbs should be grounded on the modernization of Traditional Chinese Medicine.The wholism of syndrome leads to the whole regulation of complex prescription,which is the core of treatment based on syndrome differention.Thus,we put forward the whole regulating effects in the recipe of Chinese traditional herbs,which is completely distinguished from the multi-targeting effects.A...更多s it is difficult to analyze the exact characteristics and tastes,attributive channel and ascending and subsiding of the ingredients of Chinese traditional herbs,we think it necessary to retain as many chemicals in the recipe as possible to ensure the whole effects,especially for those great amounts of low abundance substances and microelements.We suggest that much more attention be paid to the effects of gastrointestinal tracts on the recipe of the Chinese traditional herbs.The real effective molecules(drug elements or its prosome) exist in the substances which have been digested and absorbed but not yet circulated in blood, and they are the material foundation of whole effects.Based on the above findings and beliefs,we put forward the concepts of whole effective moleculeome and whole moleculeomics of the recips.

国家自然科学基金(30572334)分离纯化中约汤剂整体效应分子生物模拟技术集成研究