[关键词]
[摘要]
以中药强极性组分、类组分、同系组分、微量组分为研究重点,采用新颖的分离表征策略和发展新型分离材料进行中药标准组分系统分离制备。发展硅胶基质的亲水性色谱填料分离中药强极性组分,以组合大孔树脂技术研究类组分,发展组合分子印迹技术分离同系组分,以差异化富集策略研究微量组分。同时,采用多模式、多柱色谱及其联用技术进行标准品的制备,建立标准品资源库,推动中药物质基础的研究。
[Key word]
[Abstract]
Focusing on polar components,similar compounds,homologue components and trace compounds in Traditional Chinese Medicine (TCM),novel strategies and material are developed for systematic separation and characterization of standard multi-component collectives from TCM.Solid phase for hydrophilic interaction chromatography is devel- oping to separate polar components,resin-combination technique is suitable for similar compounds collection,multi- molecular imprinting technology is using to extract homologue components,and differential enriched strategy is ap- plied to afford trace compounds.Also,multi modes and columns chromatography as well as their coupled technolo- gies are applied to prepare standard compounds for library construction.All these works will elucidate the chemical constitution in TCM.
[中图分类号]
[基金项目]
中国科学院知识创新工程重要方向项目(KGCX2-SW-213)基于现代理论和技术的复方中药系统研究;; 国家自然科学基金重点项目(20235020)中药药效组分的指纹图谱分析的方法研究
