中药的化学表征是实现中药现代化的重要环节。本文结合中药发展的现状,从组分的角度切入中药,提出了同系组分的概念,并从标准品表征,强极性组分表征,同系组分表征,多维多模式色谱分离及其联用表征和质量控制方法与技术等方面,全面阐述了进行系统化学表征研究的思路,力求实现对中药物质基础的揭示和中药产品开发过程中的全面质量控制。

The chemical characterization of Traditional Chinese Medicine (TCM) is an important tache in the realization of its modernization.The concept of“homologue components”was brought forward to enrich the theory of multi-com- ponents Chinese medicine (MCCM) on the basis of development status of TCM.The design of the study on systemic chemical characterization was expatiated across-the-board from the following aspects:the characterization of stan- dard samples,the characterization of high polar multi-components,the characterization of“homologne components”, the separation and characterization with multi-dimension and multi-mode chromatography combined their hyphenat- ed techniques and the methods and techniques of quality controlling.The systemic technique were applied in order to thoroughly make clear of chemical constitutions of TCM and to build up the strict quality controlling system dur- ing the production of TCM

中国科学院知识创新工程重要方向项目(KGCX2-SW-213)基于现代理论和技术的复方中药系统研究;; 国家自然科学基金重点项目(20235020)