西方食品增补剂禁用麻黄后化学结构与麻黄碱相似的辛弗林（synephrine）又备受关注。本文从含量测定的角度,建立了辛弗林含量测定方法。分析了枳实、枳壳、青皮和陈皮药材共95份样品中辛弗林的含量分布情况,并采用该方法考察了新会、长沙和自贡产地自采果皮在不同采收时间内辛弗林含量变化情况。测定结果表明,青皮和枳实药材中辛弗林含量最高,约为0．6％和0．45％,陈皮和枳壳中相对略少,为0．3％和0．1％;未成熟药材（青皮）辛弗林含量比成熟果皮为高。由此推算相应的用药剂量,从而为检测和使用枳实、枳壳、青皮和陈皮等药材提供参考和依据.

The content of synephrine in herbal medicine and food supplement has been drawn more attention after the food supplements containing ephedrine was prohibited in West for its similar structure to ephedrine. In this paper, a method on determination of synephrine was established and 95 samples of the pericarp of Citrus spp. （aurantii immatus, Fructus aurantii, Pericarpium citri reticulatae viride and Pericarpium citri reticulatae） collected from different location were analyzed. The results indicate that the content of synephrine in Pericarpium citri reticulatae viride is about 0.6%, in Fructus aurantii immatus is about 0.45% and Fructus aurantii and Pericarpium citri reticulatae are about 0.1% and 0.3%, respectively. Immature fruits contain higher content of synephrine than mature fruits. The intake dose of synephrine related to the daily dose of the corresponding crude drugs were calculated according to the testing results as the guidance of appropriate dosage under consideration of safety and efficient.

国家中医药管理局资助项目(中医药科2001ZDX005)中药材质量研究