目的:观察麦角甾苷对小鼠肾毒血清肾炎的作用,以期将麦角甾苷开发成治疗肾炎的新药。方法:采用小鼠肾毒血清肾炎模型,给予麦角甾苷10、30、90mg／kg口服,给药5天和10天后作肾功能及肾组织学检测。结果:给药5天和10天后,麦角甾苷三个剂量都能明显降低尿蛋白、尿素氮、总胆固醇（p值分别<0．05,<0．01,<0．001）;明显升高白蛋白（p值分别<0．05,<0．01,<0．001）。肾组织学检测发现三个给药组肾小球基底膜增厚程度均轻于模型组,肾小管蛋白管型亦比模型组轻。结论:麦角甾苷对小鼠肾毒血清肾炎有良好的治疗作用,提示麦角甾苷对于人类免疫性肾炎可能具有一定的临床意义和应用前景。

This study is designed to observe the therapeutic effects of radix rehmanniae preparata acteoside on rat nephrotoxic sera nephritis, in an attempt to work out a new Acteoside medicine for treating the disease. The following methods are used in the study: establishing a model for rat nephrotoxic sera nephritis; oral intakes of Acteoside at a dosage of 10, 30, 90 mg/Kg respectively; kidney function and histology are measured at an interval of 5 and 10 days. It is found that all of the three dosages significantly reduce the amount of urine protein, urea nitrogen and cholesterol total （p<0.05.p<0.01 .p<0.001） 5 and 10 days after the medicines are given, with an obviously lifted albumin （p<0.05,p< 0.01 ,p<0.001）. Kidney histology shows that the three medicine-taking groups have produced a glomerular basement membrane （GBM） incrassation that is lighter than the control group, with the same result for the renal tubule albumen. It is concluded that Acteoside works effectively on rat nephrotoxic sera nephritis, which promises a possible clinical application for treating the human immunity nephritises.

中国中医科学院中日协作项目:熟地黄的药理学研究。