以血瘀证为例,按照循证医学的原则,开展了多中心、大样本的流行病学调查,获取了2004份血瘀证症状体征调查表,用隐变量分析方法对获得的症状体征数据进行了分析,建立了一个可以用中医理论解释的隐结构模型。研究表明,利用隐结构模型可以探讨中医辩证的客观化、定量化,揭示众多症状间以及症状与证候间复杂的相互关系,为中医辨证的科学发展提供依据。

Latent variable analysis is a widely used statistical method.Standardized and objective study of bloodstasis syn- drome calls for a more sophisticated approach.Latent variable analysis makes a right method for such study.In the pa- per,bloodstasis syndrome is selected as the study objective.An extensive epidemiological survey is conducted in line with the principle of evidence-based medicine.Some 2004 questionnaires concerning bloodstasis symptoms and physi- cal signs are collected,and a Latent Structure Model is established to analyze the data.The model results are interpreted using TCM theory.The study suggests that Latent Structure Model is desirable for differentiating symptoms and signs, which creates a scientific ground the further development of TCM.

国家重点基金研究发展规划项目(2003CB517103)：证候规范及其与疾病、方剂相关的基础研究—冠心病心绞痛病症结合诊断标准及疗效评价体系研究;;阶国家中医药管理局课题(02-03JP47)血瘀证病位分类与诊断研究;;国家自然基金重大计划面上项目(90209011基于计算智能的血瘀证量化诊断方法学研究