目的：探讨海昆肾喜（FPS）防治阿霉素肾病大鼠肾小球硬化的作用机制。方法：将54只Wistar雄性大鼠,随机分为6组,每周测体重,每2周收集24小时尿量,测24小时尿蛋白定量,10周后处死,分离血清观察各项生化指标,应用HE、六胺银染色及Mallory染色,观察肾组织病理学改变,实验数据用SPSS11．0进行统计学处理。结果：海昆肾喜能够减轻阿霉素肾病大鼠肾组织病理损害,增加阿霉素肾病大鼠体重,减少尿蛋白排泄、提高血TP和Alb水平,降低BUN和Scr,改善肾功能。结论：海昆肾喜能减轻阿霉素肾病大鼠的肾脏病理损害、改善肾功能、调节血脂紊乱和升高白蛋白水平,对阿霉素肾病大鼠肾小球硬化有一定的保护作用。

Objective:We To investigate the effects and mechanism of Haikunshenxi on adriamycin-induced nephrosis in rats.Methods:The 54 Wistar rats of feminine urinary protein excretion after were randomly divided into 5 groups:normal group,model group,sham operation group,Benazepril treatment group,Haikunshenxi treatment groups,Renal tissue were examined by light microscopy at the 10th week after operation.HE,masson,Mallory was applied to explore the change of histology and pathology in the renal interstitium,at one time,were examined changes of 24-hour urinary protein excre- tion,renal function、serum BUN、serum creatinine、Cho、TP、Alb.Results:Compared with the model group rats,proteinu- ria、BUN、serum creatinine Cho、TP、Alb of rats treated with Haikunshenxi were significantly reduced.Glomerulosclerosis change in Haikunshenxi were significantly ameliorated.Conclusions:Haikunshenxi could decrease 24-hour urinary pro- tein serum BUN、serum creatinine、Cho and hoisted TP、Alb.It may play important role in prevention and treatment of ad- riamycin-induced nephrosis glomerulosclerosis.

教育部“长江学者和创新团队发展计划”资助项目(IRT0413)：中医药干预多器官纤维化于异病同治、同病异治科学内涵的研究;;国家自然科学基金重点资助项目(30130220)：复方鳖甲软肝方方治多脏器纤维化德作用机理研究;;国家中医管理局中医药科研基金(2000J-P-31)：肝肾宝防治肝肾纤维化作用机理的研究