目的：通过观察兔视网膜缺血再灌注（RIR）损伤后,视网膜中丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性和形态学的变化来探讨蒙药额尔敦乌日勒对RIR损伤的保护作用。方法：将60只日本大耳白兔随机分为正常组、模型组、蒙药组及维生素E组。采用升高兔眼压到110mmHg持续60分钟的方法制作视网膜缺血再灌注模型。分别在缺血再灌注24、72、168h后测定视网膜中MDA含量和SOD活性,并作光镜切片进行形态学观察。结果：模型组视网膜的内核层变薄、细胞排列紊乱,神经节细胞明显减少、有大量空泡形成,伴随MDA含量升高和SOD活性下降。上述变化随时间延长而加重。而蒙药组内核层和神经节细胞层分别比模型组、维生素E组增厚,细胞排列整齐。MDA含量比模型组、维生素E组均明显降低,SOD活性明显升高。结论：蒙药额尔敦乌日勒能降低视网膜中MDA含量、升高SOD活性。能够清除自由基,减轻视网膜组织损伤,对视网膜缺血再灌注损伤具有保护作用。

We studied malondialdehyde (MDA) content, SOD activity, and morphological changes in rabbits' retina, after a retinal ischemia- reperfusion (RIR) injury, in an attempt to understand the protective effects of Eerduiwu Geriletu, a Mongolian medicine, on RIR injury. In the study, 60 Japanese white rabbits were randomly divided into 4 groups, including normal, model, Mongolian medicine, and vitamin E groups. A method of elevating intraocular pressure of rabbits up to 110mmHg for 60 minutes was employed to make a retinal ischemia- reperfusion model. MDA content and SOD activity in rabbits' retina were determined at 24 hr,72 hr and 168 hr respectively. Slices were observed under an optical microscope using morphological method. In the model group, retina' s inner nuclear layer became thinner, cells arrangement became disordered, and ganglion cells decreased in number, with the formation of numerous vacuoles, an increased MDA content, and a decreased SOD activity. Above mentioned changes aggravated over time. Comparing with the model group, the vitamin E group has a more thickened inner nuclear layer of retina and ganglion cells layer.On the contrary, cells arranged regularly in the Mongolian medicine group, with a significantly reduced MDA content,though an obviously elevated SOD activity. We believe that Eerduiwu Geriletu can lower down MDA content in retina,and elevate SOD activity. Meanwhile, it can eliminate free radicals, reducing damages to retina tissues, with a protective effect on retinal ischemia- reperfusion injury.