[关键词]
[摘要]
目的:研究强心胶囊对慢性心力衰竭(CHF)大鼠心功能和心肌基质金属蛋白酶MMP-1、MMP-9蛋白表达的影响,探讨MMPs在CHF发病中的作用及该胶囊防治心肌重塑的作用的机理.方法:采用腹腔注射阿霉素法制备CHF模型.各组相应处理8周后,检测血流动力学、心肌MMP-1、MMP-9表达变化.结果:强心胶囊能提高CHF大鼠 dp/dt max、-dp/dt max、LVSP水平,降低LVEDP水平,减低心脏重量指数,降低上调的MMP-1、MMP-9表达.结论:强心胶囊能够改善CHF大鼠左室收缩和舒张功能,降低上调的MMP-1、MMP-9蛋白表达及活性,可能是强心胶囊干预心力衰竭间质重塑的重要机制之一.
[Key word]
[Abstract]
We studied the effects of Qiangxin Capsule on MMP-1 and MMP-9 expression of matrix metalloproteinase in rats with congestive heart failure,in a move to understand the role of MMPs in CHF,and therapeutic effects of Qiangxin Capsule in remodeling interstitial tissue of cardiac.In the study,we established a rat model intraperitoneally injected with doxorubicin (ADM).Haemo-dynamics,MMP-1,and MMP-9 were measured 8 weeks after the injection.Results indicate that the Qiangxin Capsule has enhanced the level of +dp/...
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[基金项目]
黑龙江省科技厅科技攻关项目(GC02C123)强心胶囊治疗充血性心力衰竭的基础研究
