[关键词]
[摘要]
利用化学和细胞生物学手段,对只有两味药组成的简单复方"当归补血汤"进行了系统研究,在探讨中药复方作用机理的同时,实验结果也证明了传统中药复方共煎的合理性。通过比较共煎、分煎的当归补血汤的化学成分及生物学活性,发现中药复方共煎不仅可以促进有效成分的溶出,而且可以增强免疫活性、补血作用、类雌激素活性、成骨细胞分化活性。共煎促进了复方成分间的相互作用、相互反应,从而产生特殊的活性,体现复方疗效。
[Key word]
[Abstract]
Authors try to reveal the rationality of preparing medicinal herbs together in a traditional manner, using Danggui Buxue Tang (DBT) as an example, in an attempt to demonstrate the specific requirements for preparing the two herbs together to achieve the full chemical and biological activity. The mixed preparation enhances the solubility of chemicals, immune activity, blood effects, estrogenic activity, and osteoprotective effects. Evidently, these effects are missing in the extracts derived from from a single herb. Furthermore, the interactions between decoction components create a special activity especially enjoyed by Chinese medicine.
[中图分类号]
[基金项目]
香港特别行政区政府研究基金资助局基础研究计划项目“用蛋白组学研究当归补血汤的作用机理——中药复方的标准化研究”,项目编号HKUST6419/06M[Research Grants Council, HKSAR,China; Proteomic approach in probing the action mechanism of Danggui Buxue Tang: Asample trial in traditional Chinese medicine standardization; HKUST6419/06M],负责人:詹华强;江苏省方剂研究重点实验室开放课题基金(No.FJK2006011),负责人:詹华强。