本文通过文献研究并结合实验室工作成果,以中药活性成分口服吸收机制为出发点,提出通过改善难溶性中药活性成分的溶解度和溶出速度、控制中药活性成分在胃肠道中代谢、改善中药活性成分的胃肠吸收和转运、发挥中药组合活性成分之间的有益影响等方式提高中药活性成分的口服吸收生物利用度.

Oral administration is the most commonly used method in the preparation of the traditional Chinese medicine (TCM). TCM formula preparation is characterized by multi-component, multi-target and multi-channel, which fully reflect the feature and advantage of the TCM. However, just for this reason, we often find it difficult to explain the basis of active substances, the process of the active ingredients in vivo and the bioavailability of the TCM. As a result, no scientific system is available evaluate the rationality of the TCM in the drug delivery system, dosage and preparation selection. Based on the analysis of the oral absorption mechanism of the TCM, it is highly urgent to take appriopriate methods to enhance the oral bioavailability of the active ingredients of the TCM. With literature research and laboratory work, in this study, lots of measures were taken to enhance the oral bioavilability of the active ingredients of the TCM, such as improving its solubility and dissolution rate, controlling its metabolism and transportation in the gastrointestinal tract, and taking advantage of the beneficial effects in combination.

国家教育部重点研究项目(208051):基于酶和转运蛋白中药祖师麻口服吸收与代谢研究，负责人：狄留庆；江苏省中医药局项目(HZ 07069):基于胃肠处置的中药制剂口服给药合理性研究，负责人：狄留庆；江苏省普通高校研究生科研创新计划(2007238):祖师麻主要活性成分的口服吸收及代谢研究，负责人：单进军，狄留庆；江苏省"青蓝工程"科技创新团队支持计划(苏教师[2008]30号):中药复方新型给药系统研究，负责人：狄留庆。