目的:研究刺丹混合液对急性心肌缺血大鼠的血流动力学影响.方法:结扎左冠状动脉前降支,将充满1%肝素生理盐水的塑料导管从右颈总动脉一直插入到左心室,记录大鼠冠脉结扎15min后左心室压力变化.结果:刺丹混合液能有效对抗急性心肌缺血大鼠左室收缩峰压(LVSP)的下降(P<0.05)、有效对抗左室压力最大变化速率(±dp/dtmax)的下降(P<0.05)和左室舒张末期压(LVEDP)的升高(P<0.05),与刺五加组比较,作用优于刺五加注射液和丹参注射液单用(P<0.05).结论: 刺丹混合液对大鼠急性心肌缺血有明显的保护作用.

This work aimed to study the impact of the Salvia miltiorrhiza injection and Acanthopanax senticosus injection mixture (called CIDAN mixture below) on the hemodynamics status of acute myocardial ischemia rats. The ramus descendens anterior arteriae coronariae sinistrae of experimental rats were ligated. A plastic angio catheter full of 1% liquemine was inserted into the left ventricles from the right common carotid artery. The change of the left ventricular pressure was observed 15 min from the ligation. CIDAN mixture increased the left ventricular systolic pressure (LVSP)(P <0.05) and the left ventricular maximum pressure rate of change (± dp/dtmax)(P <0.05), and reduced the left ventricular end-diastolic pressure (LVEDP)(P <0.05) of the 15min acute myocardial ischemia rats. The results show that the mixture effect is better than that of Acanthopanax senticosus injection or Salvia miltiorrhiza injection alone, and thus effectively protect the rats suffering from acute myocardial ischemia.

黑龙江省科技厅科技攻关计划项目(2006G1067-00):中药7类新药刺丹注射液的临床前研究，负责人：李廷利。