目的：观察针刺治疗原发性高血压病（EH）的临床疗效及对E-选择素（E-selectin）、诱导型一氧化氮合酶（iNOS）、内皮型一氧化氮合酶（eNOS）的影响。方法：将60例EH患者随机分为针药组和药物组各30例，分别采用针刺联合口服非洛地平和口服非洛地平治疗，观察治疗前后血压及E-selectin、iNOS、eNOS的变化。结果：两组均能降低患者血压，但针药组明显优于药物组；针药组患者治疗后E-selectin、iNOS水平降低，eNOS水平升高，其前后比较有显著性差异（P＜0.01），药物组患者iNOS水平降低，其治疗前后比较有差异（P＜0.05）。结论：针刺降压的作用机制可能在于改善高血压病患者血管内皮细胞的功能，从而恢复E-selectin、iNOS、eNOS的正常表达水平，最终起到调节血压的效果。

This study explored the effects of acupuncture on blood pressure, E-selectin, iNOS and eNOS in the patients of essential hypertension (EH). 60 cases of EH were randomly divided into the acupuncture + medicine group with the acupuncture therapy and Felodipine + the medicine group treated with Felodipine, 30 cases in each group. The patients′ blood pressure and the contents of E-selectin, iNOS and eNOS were determined before and after the treatment. After the treatment, the blood pressure declined in both two groups, but with significant differences (P＜0.05). The acupuncture + medicine group was superior. The acupuncture + medicine group had a significantly lower content of E-selectin and iNOS and higher eNOS, while the medicine group had a significantly lower content of iNOS. Acupuncture may regulate blood pressure by improving the function of vascular endothelial cells and consequently regaining the normal level of E-selectin, iNOS and eNOS, which ultimately adjusts the blood pressure.

国家自然科学基金面上项目（30973808）：中医“圆道”理论指导下微重力干预骨髓间充质干细胞多潜能性的研究，负责人：王宗仁。