目的：探讨冠心病血瘀证Gensini积分与血管内皮因子的关系。方法：将96例冠心病血瘀证患者辨证分为气虚血瘀证和痰瘀互阻证各48例，进行冠脉造影及血管内皮因子的测定，同时采用血瘀证积分评定血瘀证程度，采用Gensini评分系统评价冠脉造影的结果。结果：气虚血瘀证血瘀证积分及冠状动脉狭窄程度高于痰瘀互阻证；血清VEGF、ET-1水平随血瘀证积分及Gensini积分增高而增高；IGF-1水平随血瘀证积分及Gensini积分增高而降低。结论：冠脉Gensini积分与血管内皮因子及血瘀证积分相关。

This work aimed to discuss the relationship between the Gensini score of blood stasis syndrome in coronary heart disease and VEGF. 96 patients with blood stasis syndrome in coronary heart disease were dialectically divided into 48 cases of qi asthenia and blood stasis and 48 cases of intermingled phlegm and blood stasis respectively. Coronary angiography was performed and VEGF was determined. At the same time, the extent of blood stasis was assessed with the blood stasis score, and the result of coronary angiography was assessed with Gensini score system. The blood stasis score and the coronary artery stenosis in qi asthenia and blood stasis were higher than that in intermingled phlegm and blood stasis; the levels of serum VEGF and ET-1 increased with the increase of the blood stasis score and Gensini score; while the level of IGF-1 decreased with the increase of the blood stasis score and Gensini score. The results show that the coronary Gensini score is in correlation with VEGF and blood stasis score.

科学技术部国家重点基础研究发展计划（2003CB517103）：冠心病病证结合诊断标准及疗效评价体系的研究，负责人：王阶。