以作者近几年研究成果为例，探讨应用液相色谱质谱联用技术进行中药质量控制研究。重点讨论中药“全成分”快速表征方法及其在中药近缘品种的鉴别和化学多型性揭示、药材初加工质量评价、炮制品与非炮制品区分、配方颗粒质量评价、活性成分资源寻找和毒性成分筛选监测等方面的应用。

In the present paper, the application of modern hyphenated chromatographic techniques, in particular the high performance liquid chromatography - mass spectrometry, in the quality control of Chinese medicines is discussed based on the recent research progress achieved in our group. Focus is put on the innovative strategies and methodologies for the holistic chemical profiling of Chinese medicines by LC-MS, as well as their application in authentication of raw materials, evaluation of post-harvest handling, discrimination between raw and processed herbs, quality control of water-extracts granules, exploration of new resources for bioactive components, and detection of toxic components.

本课题由香港赛马会慈善基金会赞助。