目的：比较养心安神药和重镇安神药改善睡眠时相作用的异同。方法：在恒温、恒湿、自动光控和电磁屏蔽实验条件下，采用多导睡眠描记方法，观察养心安神药与重镇安神药对大鼠睡眠时相的影响。结果：柏子仁（Semen Platycladi）、远志（Radix Polygalae）可延长失眠大鼠睡眠时相中的SWS1期，但不缩短SWS2期和REMS期；酸枣仁(Semen Ziziphi Spinosae)延长失眠大鼠的SWS1期和SWS2期；磁石(Magnetitum)、朱砂(Cinnabari)同时延长SWS1期、SWS2期和REMS期。结论：养心安神药对REMS期无影响，而重镇安神药对REMS期有影响；与养心安神药相比，重镇安神药的磁石、朱砂对失眠大鼠的慢波睡眠延长作用更明显，可显著提高失眠大鼠的睡眠质量。

This work aimed to compare and analyze the effect of the tranquilizer of Zhongzhen Anshen and Yangxin Anshen. Polysomnography was used to record the changes of EEG and EMG in rats at different sleeping phases. The influences of Yangxin Anshen and Zhongzhen Anshen on EEG and EMG were observed. Baiziren and Yuanzhi of Yangxin Anshen increased SWS1. Suanzaoren of Yangxin Anshen increased SWS1 and SWS2. Cishi and Zhusha of Zhongzhen Anshen both prolonged SWS1, SWS2 and REMS. Taken together, Yangxin Anshen and Zhongzhen Anshen have distinct effects on ofinsomnia rats at the sleeping phase. Zhongzhen Anshen could prolong REMS, but Yangxin Anshen could not. Cishi and Zhusha of Zhongzhen Anshen could markedly prolong SWS of insomnia rats, thus better improving the sleep quality of insomnia rats.

国家中医药管理局中医药科学技术研究专项（04-05JP20）：养心安神与重镇安神治法改善睡眠机制的比较研究，负责人：李廷利。