目的：观察伤益气雾剂中栀子苷透皮吸收的特点，探讨伤益气雾剂外用时栀子苷的透皮吸收的动力学。方法：利用体内外实验对栀子苷透皮量及其血药浓度进行测试观察。结果：无论体内体外试验均表明，给药后半小时栀子苷即可透过皮肤，在皮下组织中分布，同时血中也能明显测到栀子苷。其透出量具有累积增多的线性关系。结论：伤益气雾剂中栀子苷可明显透过皮肤，并在皮下组织及血液中分布。本实验为该药外用治疗相关病症的应用提供了实验依据。

The transdermal behavior of geniposide was observed by using Shangyi aerosol for mice, and of the geniposide pharmacokinetics of this aerosol was studied. The geniposide concentration was determined in vitro and in vivo by the HPLC assay. Geniposide penetrated the skin 30 min after the aerosol use, and was found distributed in the hypodermis and the blood. The penetration of geniposide showed a positive linear relation. The results showed that geniposide of Shangyi aerosol could penetrate the skin both in vivo and in vitro, and be quickly distributed in the subcutaneous tissue and blood, which shows the use potential of the aerosol in clinics.

云南省科技厅科技创新强省计划（省院省校科技合作专项）（2008AD015）：金品 系列彝族药作用机理的深入研究，负责人：朱兆去，杜力军，赵毅。