在综述数学模型研究中药药理、总结其发展动态的基础上，引入复杂系统、复杂网络和定性数学相关理论，从中药复方的特点寻找最适合的数学描述工具，提出基于博弈的组合成分模型、基于粗糙集的组合系统模型、基于分子网络调控的组合靶点模型，并在上述数学模型的基础上基于定性因果推理提出综合模型———多源因果法，为中药复方研究提供新的思路。

A combination of qualitative and quantitative analysis is more convenient for comparison of Traditional Chinese Medicine, and more conceivable for secondary development of Chinese herbal formulae. This can better elucidate the action characteristics better and further demonstrate TCM reliability. However, no quantitative index is available in the existing model. Based on complex system theory, complex network theory and qualitative mathematics, we present the combined components evaluation-based game theory, multi-level evaluation-based rough set theory, and targets evaluation-based molecular interaction network. With these models, we put forward a comprehensive evaluation model using multi-source causality theory. The new method reflects the characteristics of Chinese herbal compounds, that is, multi-component, multi-level and multi-target, and gives a new insight into the understanding of Chinese herbal formulae.

国家自然科学基金重点项目（30730112）：四物汤作用机理的系统研究，负责人：高月；国家自然科学基金面上项目（81001699）：四物汤复方作用机理的数学模型研究，负责人：刘明。