目的：观察秦皮水煎剂对SD 大鼠胚胎/胎儿发育的影响。方法：采用SD 孕鼠，分为溶媒对照组、秦皮组，每组20 只交配成功动物，于妊娠第6 日开始至妊娠第17 日经口灌胃给予秦皮水煎剂27.3g（生药）·kg-1，每天1 次，于妊娠第20 天解剖。观察母体动物的临床症状、体重变化、摄食量、母体动物的黄体数、着床数、胚胎生存死亡情况、生存胎仔的性别、体重、外观、骨骼及内脏检查等指标；结果：秦皮组于妊娠第6~12d 引起SD 妊娠大鼠摄食量显著降低，停药后，摄食量显著增加，雄性与雌性胎儿体重较对照组明显增高，其余母体及胚胎/胎儿发育各项指标未见明显影响。结论：在本实验条件下，秦皮水煎剂未见明显的母体毒性与胚胎/胎儿发育毒性。

The potential for Cortex Fraxini decoction to induce developmental toxicity was investigated in SD rats. Timed-pregnant SD rats (20 rats/group) were given Cortex Fraxini decoction (27.3g (herbal raw material)/kg/day) or vehicles (distilled water) by gavage on gestation days 6 through 17. Maternal clinical sign, abortions, premature deliveries, and body weight were monitored throughout gestation. At termination (gestation days 20) pregnant females were evaluated for clinical status and gestational outcome; live fetuses were examined for gender, external, visceral and skeletal malformation and variations. No deaths, premature deliveries or dose-related clinical signs were attributed to Cortex Fraxini decoction. Maternal body weight and body weight gain were not affected. Food consumption was significantly decreased from GD6 to GD12 and increased from GD18 to GD 20. Fetal weights were statistically increased. There were no effects observed on fetus viability, incidences of fetal malformation and variation. These results demonstrate that Cortex Fraxini decoction has no detectable adverse effects on either the treated F0 female rats or the fetuses.

科学技术部国际科技合作项目(2006DFB31690)：促进中药材在法国的注册和进入，负责人：林瑞超。