疾病分类与证候分类结合的诊疗模式已经成为中医学和中西医结合医学临床实践的主要模式。本研究以类风湿性关节炎（RA）为例，比较RA 寒热证候与临床疗效的关联、寒热证候实验室常规指标及组学指标的差异，指出RA 寒热证候存在客观生物学基础，有助于RA 临床诊断和有效治疗。

An integrative mode of the disease classification in Western medicine and the syndrome differentiation in Chinese medicine is already the chief mode of sorting applied in clinical practice of Chinese medicine and integrative medicine. In this study, the cold and heat pattern of rheumatoid arthritis were comparatively analyzed. A range of facts, including the correlation of syndrome differentiations and therapeutic effects, the difference of laboratorial examination and omics expression between cold and heat pattern of RA were reviewed to demonstrate the biological basis of RA syndrome differentiations. It indicates that the better knowledge of the biological basis involved in syndrome differentiations of Chinese medicine might help to choose the most appropriate treatment.

科学技术部“十一五”国家科技支撑计划项目（2006BAI04A10）：基于二次临床研究的中医药治疗类风湿性关节炎的临床评价，负责人：吕爱平；科学技术部国家“重大新药创制”科技重大专项项目（2009ZX09502原0190）：基于辨证论治治疗RA 中药新药药效评价动物模型研制及其应用研究，负责人：吕爱平；国家科学技术部创新方法学专项项目（2008IM020900）：中医药科学方法研究——中医药科学方法总论研究，负责人：吕爱平；国家自然科学基金杰出青年项目（30825047）：中西医结合基础——疾病证候分类研究，负责人：吕爱平；国家自然科学基金项目（30902000）：基于肾阳虚关节炎大鼠壮骨关节丸毒性反应评价研究，负责人：吕诚。