本研究以中国生物医学文献数据库为载体，类风湿性关节炎、痛风及骨性关节炎为研究对象，采用数学和统计的方法，获取高频率、协同出现的关键药对，探寻中医治疗这3 种疾病的用药规律。结果显示，当归、黄芪、桂枝、芍药等为中药治疗类风湿性关节炎核心药物。牛膝、茯苓、黄柏、大黄等为治疗痛风核心药物。当归、独活、牛膝、白芍等为治疗骨性关节炎核心药。分析结果可知中医在治疗类风湿性关节炎、痛风及骨性关节炎时，大都采用活血化瘀的治疗方法。此外，在治疗类风湿性关节炎和骨性关节炎时多采用祛风湿法，在治疗痛风时多采用利水湿法。

In this research, we select Chinese BioMedical Literature Database as vector to analyze the Chinese herb medication regularity of rheumatoid arthritis, gout and osteoarthritis. The high frequency and synergism herbs pattern are obtained. The results show that The key herbs of traditional Chinese medicine treatment of rheumatoid arthritis are Dang Gui (Radix Angelica), Huang Qi (Astragalus membranaceus (Fisch.)Bunge), Gui Zhi (Rhizoma pinelliae), Shao Yao (Radix paeoniae alba) and so on. The key herbs of traditional Chinese medicine treatment of gout are Niu Xi (Achyranthes bidentata), Fu Ling (Wolfiporia cocos), Huang Bai (Phellodendron amurense Rupr. ), Dai Huang (Rhizoma et Radix Rhei) and so on. The key herbs of traditional Chinese medicine treatment of osteoarthritis are Dang Gui (Radix Angelica), Du Huo (Radix angelicae biseratae), Niu Xi (Achyranthes bidentata), Bai Sao (Radix paeoniae alba). The results suggest that the TCM treatment of rheumatoid arthritis, gout and osteoarthritis usually use the treatment of promoting blood circulation. In addition, the therapy method of Dispelling Wind-wet usually used in treating rheumatoid arthritis and osteoarthritis, the therapy method of promoting urination usually used in treating gout.

科技部“十一五”国家科技支撑计划项目（2006BAI04A10）：基于二次临床研究的中医药治疗类风湿性关节炎的临床评价，负责人：吕爱平；国家科学技术部“重大新药创制”科技重大专项项目（2009ZX09502原0190）：基于辨证论治治疗RA 中药新药药效评价动物模型研制及其应用研究，负责人：吕爱平；国家科学技术部创新方法学专项项目（2008IM020900）：中医药科学方法研究——中医药科学方法总论研究，负责人：吕爱平；国家自然科学基金项目（30902003）：基于生物网络构建技术的中药寒热药性科学基础，负责人：姜淼；中国中医科学院自主选题项目（Z0134）：关节性疾病病证结合临床基础研究，负责人：姜淼。