目的：运用数据挖掘方法，挖掘单味药、药对之间的关联关系，分析类方和药对内部的组成关系，探讨四物汤的配伍规律。方法：收集四物汤类方3487首，针对四物汤药物配伍和药对特征，对单味药、药对之间的关联关系，分别采用频繁模式、FP-Growth算法。结果：获得置信度>0.15的四物汤配伍常用药有甘草、人参、肉桂、茯苓，常用药对有当归-甘草、川芎-甘草、地黄-甘草、芍药-甘草、人参-甘草、茯苓-甘草。结论：四物汤常用配伍主要有补益药、行气药、温里药、清热药、活血化瘀药，并由此形成常用药对，在妇科疾病的治疗中得到了广泛的应用。

The compatibility laws of Siwu Tang are explored by studying the association relations of a single herb or herb-pair with data-mining and analyzing the inner composition relation of associated prescriptions and herb-pair. Based on the collected 3487 associated prescriptions of Siwu Tang, the frequent patterns and FP-Growth algorithm are used to detect the association relations of a single herb or herb-pair according to the features of the herb-pair and compatibility of the drugs in Siwu Tang. The herbs in Siwu Tang whose confidence level is higher than 0.15 are found to be Gancao (glycyrrhiza), Renshen (ginseng), Rougui (cassia), Fuling (poria), while the common herb-pair has Danggui-gancao (Angelica-glycyrrhizae), Chuanxiong-gancao (LigusticiChuanxiong-glycyrrhiza), Dihuang-gancao (Rehmanniae-glycyrrhiza), Shaoyao-Gancao (Radix Paeoniae-glycyrrhiza), Renshen-Gancao (ginseng-glycyrrhiza), and Fuling-Gancao (poria-glycyrrhiza). The results show that the herbs for invigorating, moving qi, warming the interior, clearing away heat, activating blood and removing the stasis are often used together in Siwu Tang, therefore forming herb-pairs, which are widely used in the treatments of gynecopathy.

江苏省中医药局康源基金创新项目（HZ0801KY）：特征性关联方药数据库与知识挖掘2008-2010，负责人：范欣生；江苏省教育厅重点研究项目（06KJA36022）：四物汤类方治疗妇科血瘀证痛经的配伍规律和物质基础研究，负责人：段金廒。