目的：研究胆酸包合物对鼻粘膜刺激性及其抗炎作用的影响。方法：采用在体蟾蜍上颚模型法，研究胆酸包合物对鼻粘膜刺激性的影响；采用二甲苯致小鼠耳肿胀试验、醋酸致小鼠腹腔毛细血管通透性试验、小鼠棉球肉芽肿试验，研究胆酸包合物抗炎作用的影响。结果：胆酸经羟丙基-β-环糊精包合后，其纤毛毒性得到了明显的改善，相同浓度下的胆酸和包合物对比有显著性差异（P＜0.01）；相同剂量的胆酸和包合物抗急、慢性非特异性炎症作用对比无显著性差异（P＞0.05)。结论：羟丙基-β-环糊精可以改善胆酸对鼻粘膜刺激性，且不影响其抗炎作用，表明采用羟丙基-β-环糊精制备胆酸包合物可以解决胆酸经鼻给药的关键性问题。

This work aimed to study the effects of hydroxypropyl-β-cyclodextrin on nasal mucosa irritation and the anti-inflammatory effect of cholic acid. Various sample solutions were given to detect the ciliary beat time by the toad palate model in vivo. The anti-inflammatory effect was studied by a few conventional models, such as ear edema induced by xylene, granuloma induced by cotton ball, and capillary permeability in abdominal cavity by ethanoic acid in mice. With the inclusion of hydroxypropyl-β-cyclodextrin, cholic acid had its cilium toxicity significantly reduced, and significant differences were observed in the cilium toxicity between the cholic acid with and without the inclusion of hydroxypropyl-β-cyclodextrin at the same concentration(P＜0.01); the anti-inflammatory effect of cholic acid was not affected, and no significant difference was found in the anti-acute and chronic non-specific inflammation effect between the cholic acid with and without the inclusion of hydroxypropyl-β-cyclodextrin at the same dose(P＞0.05). The results show that HP-β-CD has many effects on CA, such as reducing irritation to nasal mucosa significantly. Meanwhile, it has no influences on the anti-inflammatory function. Thus, this research method is feasible.