目的：观察羌药铁棒锤炮制品的抗炎、镇痛作用及初步安全性评价。方法：KM小鼠单次灌胃给药后，观察铁棒锤生品及不同炮制品的中毒情况，计算LD50或最大给药量；分别采用二甲苯致小鼠耳廓肿胀模型和琼脂致小鼠肉芽肿模型观察铁棒锤炮制品的抗炎活性；冰醋酸致小鼠扭体实验观察炮制品的镇痛活性。结果：铁棒锤生品的LD50为0.9605g·kg-1，而160~180℃、200~220℃和240~260℃砂炒炮制品的最大给药量分别为17.492、16.836和16.840g·kg-1。其中160~180℃和200~220℃砂炒炮制品均能显著降低二甲苯所致的小鼠耳廓肿胀，并对琼脂致小鼠肉芽肿有明显的抑制作用，对小鼠冰醋酸致扭体疼痛，能明显减少动物扭体次数，延长扭体潜伏期，表现出一定的抗炎、镇痛作用，尤以160~180℃砂炒炮制品疗效更优。结论：铁棒锤生品毒性较大，经炮制后毒性明显降低，其中以160~180℃砂炒炮制品疗效更优，具有明确的抗炎、镇痛作用，适用于临床内服，这也体现了中医 “减毒存性”的炮制特色。

This work aimed to observe the anti-inflammatory and analgesic effects of a processed Qiang drug, A. pendulum, and to evaluate its safety. KM mice were treated with single intragastric administration, and the toxic effects of raw materials and different processed A. pendulum were observed. The LD50 or Mmax was calculated, the anti-inflammatory effects were investigated by the ear edema induced by dimethylbenzene and agar granuloma of mice, and the analgesic effect on writhing induced by acetic acid was observed. The LD50 of the raw materials was determined to be 0.9605 g/kg，and the Mmax of the 160-180℃, 200-220℃ and 240-260℃ processed drugs was respectively 17.492, 16.836 and 16.840 g/kg. The 160-180℃ and 200-220℃ processed drugs had significant anti-inflammatory and analgesic effects, and the 160-180℃ processed drugs were better than the 200-220℃ processed drugs. Taken together, the raw materials of A. pendulum are extremely toxic, but the processed drugs are much safer; the 160-180℃ processed drugs have significant anti-inflammatory and analgesic effects, and they are suitable for oral administration. This gives a good example for the saying "reduce toxicity while keep effect", which is the feature of Traditional Chinese Medicine.

科学技术部国家“十一五”科技支撑计划（2007BAI48B08）：特色民族药（羌药）铁棒锤的特殊炮制技术研究，负责人：张艺。