目的：研究热毒宁注射液中栀子苷、绿原酸在大鼠体内的药代动力学特征。方法：大鼠尾静脉分别注射5.20、10.40、16.00g（生药）·kg-1热毒宁注射液后，收集血浆样本，采用HPLC检测栀子苷与绿原酸的血药浓度，以DAS 2.0软件计算药代动力学参数。结果：不同给药剂量下栀子苷与绿原酸的体内平均半衰期分别为41~52min、37~52min，栀子苷、绿原酸的AUC（0-t）与剂量成正比。结论：栀子苷和绿原酸在体内的动力学过程均可用二室模型来描述，且二者在大鼠体内呈线性代谢。

This work aimed to investigate the pharmacokinetic parameters of geniposide and chlorogenic acid after administration of reduning injection. The rats were given three doses of reduning injection by the tail vein. The plasma was collected, and the HPLC method was used to determine the concentration of geniposide and chlorogenic acid in plasma. The concentration-time curves were described and pharmacokinetic parameters were analyzed by program DAS 2.0. After the administration of different doses, the half-life of geniposide and chlorogenic acid in rats were respectively 41-52 min and 37-52 min, with their AUC(0-t) being propotional to the dose. The results show that the concentration-time of geniposide and chlorogenic acid in rats could be described by a two-compartment model, suggesting that two ingredients would present linear pharmacokinetics.

科学技术部国家重大新药创制（2009ZX09313-032）：创新中药中试放大研究技术平台，负责人：萧伟。