目的：通过确定细辛超微粉体制备工艺，探讨了粉碎过程对其挥发性成分的影响。方法：以细辛粉末粒径分布D90 及D50 值为指标，初步筛选出细辛超微粉碎工艺最佳时间；采用毛细管气相色谱法测定细辛细粉和不同粒径超微粉中甲基丁香酚及黄樟醚的含量。采用红外光谱法观测超微粉碎前后细辛化学成分的变化。结果：振动磨粉碎可实现细辛药材的细胞破壁；于低温下粉碎未造成细辛中挥发性成分的损失，振动粉碎6min 时甲基丁香酚含量最高，振动粉碎12min 时黄樟醚含量最高，细辛经超微粉碎后其成分未发生变化。结论：本研究初步表明超微粉碎工艺适用于细辛粉末的制备。

The study aimed to determine the preparation process of micron particles of Asarum, and to investigate impact on volatile components during the process of ultra-fine pulverization. The particle size distribution value of Asarum was defined as D90 and D50. The best time of Asarum pulverization was preliminary screened. Capillary gas chromatography was used to compare the methyleugenol and safrole content of Asarum powders of different sizes. Infrared spectrometry was applied to determine the chemical composition change of Asarum before and after pulverization. Results show that vibration mill grinding is able to break the cell wall, and yet cause no loss of volatile components in Asarum at low temperature. Content of methyleugenol reaches to the highest level at 6 minutes during vibration grinding process, but the content of safrole reaches to the highest level at 12 minutes. No chemical composition change of Asarum had been detected after ultra-fine pulverization. Preliminary study proved that ultra-fine pulverization techniques can be used for Asarum powder preparation.

国家中医药管理局中医药行业科研专项资助项目（200807054）：赤芍、马钱子等40 种中药粉体标准的研究，负责人：蔡光先。