目的：优选注射用活血通络中超临界CO2 萃取川芎脂溶性成分的工艺条件。方法：以川芎脂溶性成分得率和藁本内酯、阿魏酸的含量为指标，采用正交试验法优选超临界CO2 萃取川芎脂溶性成分的工艺条件。结果：最佳工艺条件：萃取温度50益，压力35MPa，时间1h。结论：该提取工艺条件稳定可行。

The study aimed to optimize the conditions of supercritical fluid extraction for fat-soluble ingredients of Ligusticum chuanxiong Hort. The fat-soluble ingredients, content of Ligustilide, and content of ferulic acid were used as the indexes in this study. The extraction technology for fat-soluble ingredient of Ligusticum chuanxiong Hort was optimized by the orthogonal design. Results showed that the optimal extraction conditions were at the temperature of 50℃, and the pressure of 35 Mpa for one hour. The conclusion is that the extraction technology was stable and feasible.

科学技术部国家重大新药创制项目（2009ZX09313-032）：创新中药中试放大研究技术平台，负责人：萧伟。