动物药是我国传统中药的重要组成部分，但由于其组成复杂，分离较困难，与植物药相比动物药的研究相对落后。动物药组成中蛋白质占很大比例，目前已从动物药中发现许多蛋白质和多肽类活性组分。蛋白质组学、肽组学技术是快速发展的大规模表征蛋白质、肽的技术，借助蛋白质组学、肽组学快速、高效的特点，将蛋白质组学、肽组学技术应用于动物药中蛋白质和肽类活性组分的研究是动物药新的研究方向。本文综述了近年来应用蛋白质组学和肽组学技术研究动物药中蛋白质和肽类活性组分的进展。

Chinese Materia Medica (CMM) is composed of plants, animals and minerals. Compared with herbal medicine, most bioactive components in animal medicine are macromolecules, such as proteins and peptides. Although many bioactive proteins and peptides have been revealed from animal medicine, it is still a time-costing and labor-consuming work to separate and purify proteins and peptides from the extraction mixture of animal medicine. Proteomics and peptidomics are high-throughput approaches in proteome and peptide analysis. Hence, both methods are applied on screening bioactive proteins and peptides of animal medicine in this study. Progress of the application of proteomics and peptidomics on bioactive proteome and peptides in CMM animal medicine are reviewed in this article.

中国科学院绿色农业技术集成与发展中心创新方向项目（KSCX2-YW-N-093）：鹿血生物活性组分的制备和应用，负责人：靳艳。