[关键词]
[摘要]
三氧化二砷作为剧毒药广为人知,传统中药称其为"砒霜",而从中药砒霜中诞生的亚砷酸注射液其治疗急性早幼粒细胞白血病的疗效又为世人所瞩目,但仍伴随不同程度的不良反应。本文主要介绍了三氧化二砷的代谢途径及急慢性毒性机制,提出亚砷酸注射液不良反应的机制假设,为研究开发消除不良反应的药物提供依据。
[Key word]
[Abstract]
Arsenic trioxide is well known as a deadly poison.However,arsenous acid injection,which is originated from white arsenic in traditional Chinese medicine(TCM),has great efficacy in the treatment of acute promyelocytic leukemia(APL).This medication is still accompanied with some severe adverse drug reactions(ADR).This paper tried to discuss metabolic pathways,as well as acute and chronic mechanisms of arsenic trioxide.The hypothetic ADR mechanism of arsenous acid injection was proposed to provide basis for new drug discovery in order to eliminate ADR.
[中图分类号]
[基金项目]
科学技术部行业专项(200807014):基于代谢组学的有毒中药毒性机理及解毒方法研究,负责人:王喜军
