动脉粥样硬化是心脑血管疾病的主要病理基础，血小板单核细胞粘附聚集在急性心脑血管疾病的发病中占有重要地位，本文就此聚集体的形成的分子机制、诱使斑块破裂的机理、影响急性心脑血管疾病的病机、中西药物的作用靶点及相应的单克隆抗体和基因敲除等进行综述，并就目前研究中存在的问题进行剖析，以期引起同道的重视。

Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases. Adhesion and aggregation of platelet and monocyte play an important role in patients with acute cardiovascular and cerebrovascular diseases. This article reviewed molecular mechanism of aggregation formation, mechanism of inducing plaque rupture, pathogenesis of impacting acute cardiovascular and cerebrovascular disease occurrence, targets of Chinese medicine and western medicine, and corresponding monoclonal antibodies and gene knockout, etc. Problems existed in the current study were also analyzed in order to arouse the attention of fellow researchers.

国家自然科学基金面上项目（30901904）：四妙勇安汤及有效单体干预动脉粥样硬化PMA及MMP-1，2，3，9，13相关表达的研究，负责人：彭立；天津市自然科学基金重点项目（09JCZDJC20700）：从细胞粘附角度探究四妙勇安汤干预易损斑块的分子机制，负责人：张军平。