目的：考察白芍、牡丹皮共有成分芍药苷的大孔树脂纯化工艺。方法：以芍药苷为指标，考察了树脂型号、洗脱溶媒以及树脂重复使用对其吸附、解吸的影响。结果：选用D101大孔吸附树脂，30%乙醇洗脱，洗脱率达到90.07%。树脂可重复使用18次后，再彻底进行活化再生。结论：D101大孔吸附树脂适用于白芍、牡丹皮共有成分芍药苷的富集。

This study aimed to evaluate the purification technology on macroporous resin, which existed both in Radix Paeoniae Alba and Cortex Moutan. Paeoniflorin is used as an index for the evaluation of resin model, elution solvent and adsorption and desorption effects of reused resin. The results showed that the elution rate of using D101 macroporous resin and 30% ethanol elution is 90.07%. And after 18 times repetitive using, the resin can be thoroughly activated and regenerated. It is concluded that the D101 pocket polymeric adsorbent is suitable for the concentration of paeoniflorin in both Radix Paeoniae Alba and Cortex Moutan.

科学技术部国家重大新药创制项目（2009ZX09313-032）：创新中药中试放大研究技术平台，负责人：萧伟。