对于巴金森氏病人而言,因针灸的安全性且其与抗巴金森药物无交互作用,所以常作为辅助性的疗法。然而针灸对巴金森氏病的临床疗效是有争议的,而且少有用电生理的研究来评估针灸对巴金森氏病的影响。因此,本文设计电生理试验以衡量巴金森氏病人的头皮针治疗,我们使用皮质应激性(经成双穿颅磁刺激所诱发)为电生理评估的工具,对9位巴金森氏病人进行头皮针的试验并分析前后电生理变化。经头皮针的短暂治疗后6位巴金森氏病人并未在肢体活动获得短期的改善,但无任何不适的并发症。但是在头皮针的治疗前后确有明显的电生理改变,于巴金森氏病人中发现,其于成双穿颅磁刺激中存在对运动皮质应激性抑制。因此,进一步长期临床与生理机制评估是必需的。

Acupuncture was frequently used for alternative treatments in Parkinson’s disease because of its safety,but there was an argument whether acupuncture improves motor symptoms or not.Besides,few electrophysiological studies were designed for acupuncture combined with Parkinson’s disease Using the technique of paired transcranial pulse magnetic stimulation,we measured the excitability of corticocortical inhibitory circuits to investigate effects of scalp acupuncture from 9 patients with Parkinson’s disease.Although patients didn’t take any short-term benefit in motor symptoms through the treatment of scalp acupuncture,there was no any adverse event,and some electrophysical effects developed in patients.The enhanced corticocortical inhibition on motor cortex possibly developed at longer interstimulus intervals,and there was a relatively increase in later part of motor-related cortical potentials on the central part and right-side near vertex around over sensory cortex,but was not significant in early potentials.So a further long-term study is essential to ascertain the physical mechanism and clinical effects in scalp acupuncture.

科学技术部国家“十一五”科技支撑计划项目(2007BAI07A23):便携式辅助诊疗设备开发和导航针刀应用技术开发,负责人;杨学智;教育部创新工程重大项目培育资金(v200801):指感施压和微阵列传感的中医脉诊信息获取技术,负责人:牛欣