目的：阐明脾虚气陷、贲门失固是胃食管反流病的重要发病机制，治疗应以脾虚论治、补脾论治、补脾升提和固摄贲门为基本治则。方法：通过现代医学对该病发病机理与中医脾虚病机的关联性及现代医学的治疗原则与中医补脾气治疗的关联性论述，阐明脾虚在该病发病中的重要性。结果：补脾固贲汤为治疗该病的有效方剂。结论：补脾固贲汤具有补脾固贲和胃降逆的功效，治疗胃食管反流病疗效显著，无明显不良反应，是一种安全有效的治疗方法。

This study was aimed to discuss important factors of spleen and stomach deficiency in gastroesophageal reflux disease (GERD). The basic Chinese medicine treatment principle of GERD is to strengthen the spleen and the stomach. Literature reviews of GERD pathology in modern medicine and the treatment principle in TCM theory were searched. Literature review presents that the deficiency of spleen and stomach is an important factor in GERD. The result showed that Bupi-Guben decoction was an effective prescription in the treatment of GERD. It is concluded that Bupi-Guben decoction is effective in strengthening the spleen and descending stomach qi in GERD treatment with no obvious side effect. It is a safe and effective treatment method.

国家中医药管理局陕西中医学院附属医院脾胃病重点学科，学科带头人：沈舒文。